Recurrent Abdominal Pain

Definition

Episodic or continuous abdominal pain lasting for a period of at least 2 months.
Affects approximately 10% of school-aged children.
Often referred to as functional abdominal pain when no underlying organic cause is identified.

Diagnosis relies on symptom-based Rome IV criteria.
Requires absence of organic, inflammatory, anatomic, metabolic, or neoplastic processes explaining symptoms.
Pathophysiology frequently linked to visceral hyperalgesia and disordered brain-gut communication.

Subtype	Diagnostic Criteria
Functional abdominal pain - not otherwise specified	Episodic or continuous periumbilical pain occurring $\geq$ 4 times/month for >2 months; insufficient criteria for other functional disorders.
Irritable bowel syndrome	Abdominal pain $\geq$ 4 days/month associated with defecation, change in stool frequency, or change in stool form.
Functional dyspepsia	Postprandial fullness, early satiety, epigastric pain/burning not relieved by defecation.
Abdominal migraine	Paroxysmal intense periumbilical/midline pain >1 hour; associated with anorexia, nausea, vomiting, headache, photophobia, pallor.

Functional diagnosis requires rigorous exclusion of alarm signs.
Involuntary weight loss, deceleration of linear growth, delayed puberty.
Gastrointestinal blood loss (hematochezia, melena, occult blood).
Chronic severe or nocturnal diarrhea.
Persistent right upper or right lower quadrant pain.
Unexplained fever, arthritis, spinal tenderness, perianal disease.
Family history of inflammatory bowel disease, celiac disease, or peptic ulcer disease.
Pain awakening child from sleep.

Avoid extensive invasive testing if typical functional features exist without red flags.

Investigation	Rationale
Complete blood count	Exclude anemia, underlying infection.
Inflammatory markers (ESR, CRP)	Rule out systemic inflammation or inflammatory bowel disease.
Comprehensive metabolic panel	Assess hepatic and renal function.
Celiac serology	Measure tissue transglutaminase IgA, total serum IgA.
Stool analysis	Check for occult blood, ova/parasites, Giardia.
Fecal calprotectin	Differentiate functional pain from inflammatory bowel disease.
Urinalysis	Exclude urinary tract infection.

Validate patient symptoms; pain is real, not imagined.
Educate parents and child regarding brain-gut axis and visceral hyperalgesia concepts.
Reassure regarding benign, non-progressive nature of ailment.
Normalize lifestyle; discourage school absenteeism; minimize excessive parental attention to pain behavior.
Implement cognitive behavioral therapy, gut-directed hypnotherapy, or guided imagery to enhance coping mechanisms.

Provide well-balanced, nutritious diet with adequate fiber.
Restrict excessive intake of carbonated beverages, refined foods, and fruit juices (sorbitol/fructose).
Consider temporary low-FODMAP diet if pain associates heavily with bloating.

Avoid unnecessary medication; utilize empiric therapies for refractory symptoms affecting quality of life.
Antispasmodics: Peppermint oil or hyoscyamine for irritable bowel syndrome.
Probiotics: Lactobacillus rhamnosus GG administration may reduce abdominal pain frequency and intensity.
Neuromodulators: Amitriptyline or selective serotonin reuptake inhibitors (SSRIs) indicated for severe, disabling pain with comorbid anxiety or depression.
Cyproheptadine: May improve gastric accommodation in functional dyspepsia.